Journal article
Biological sex influences antibody responses to routine vaccinations in the first year of life
P Zimmermann, KP Perrett, N Ritz, KL Flanagan, R Robins-Browne, FRM van der Klis, N Curtis, V Abruzzo, K Allen, R Bonnici, D Casalaz, H Elborough, B Freyne, K Gardiner, S Germano, T Kollmann, N Messina, C Morrison, H Nakaya, AL Ponsonby Show all
Acta Paediatrica International Journal of Paediatrics | WILEY | Published : 2020
DOI: 10.1111/apa.14932
Abstract
Aim: We investigated the effect of early-life factors, namely sex, delivery mode, feeding method and antibiotic exposure, on antibody responses to routine vaccinations administered during the first year of life. Methods: One and seven months after the primary course of routine vaccines and 1 month after routine vaccines at 12 months of age, antibodies against 26 vaccine antigens were measured in 398 healthy infants. The geometric mean concentration (GMC) of antibodies (adjusted for effect modifiers with multiple linear regression) and the seroprotection rate for each vaccine were compared for each early-life factor. Results: Sex had an influence on GMCs. Antibody concentrations were signific..
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Awarded by University of Melbourne
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (NHMRC) (grants GNT1051228 and GNT1099680), the University of Melbourne (International Research Scholarship to PZ) and the European Society of Paediatric Infectious Diseases (ESPID) (fellowship to PZ).