Colorectal peritoneal metastases: Exploring the immune landscape and the potential of immunotherapy using organoid models

Abstract

Abstract Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Up to half the patients with CRC will develop metastatic disease, with an associated 5-year survival of 13.5%. The peritoneum is a common site for metastases, but carries the worst prognosis among all sites. Most patients with colorectal peritoneal metastases (CRPM) are inoperable, leaving systemic chemotherapy as the only treatment option. With systemic therapy alone, only 4% of patients with CRPM are alive at 5 years. Immunotherapy, while effective in a number of cancers, remains unexplored in peritoneal disease. Here, we aim to firstly explore the immune landscape of CRPM, and subsequ..