Conference Proceedings
Association of the imbalance between early and late differentiated intra-tumor CD4 T cells with mutational burden in non-small cell lung cancer.
Ehsan Ghorani, James L Reading, Jake Y Henry, Marc Robert De Massy, Rachel Rosenthal, Andrew JS Furness, Assma Ben Aissa, Mariam Jamal-Hanjani, Nicolai Birkbak, Gareth Wilson, Roberto Salgado, Tom Lund, Crispin T Hiley, Sherene Loi, Allan Hackshaw, Nicholas McGranahan, Benjamin M Chain, Karl S Peggs, Charles Swanton, Sergio A Quezada
JOURNAL OF CLINICAL ONCOLOGY | AMER SOC CLINICAL ONCOLOGY | Published : 2019
Abstract
2590 Background: CD4 T helper cells are key orchestrators of immunity in states of persistent antigen exposure. In chronic viral infection, loss of immune control is associated with CD4 differentiation skewing (CD4ds) resulting from decline of early progenitors and gain in abundance of exhausted and terminally differentiated subsets. Here, we set out to identify whether a similar process occurs within the tumour microenvironment, contributing to immune dysfunction. Methods: Multiregional samples of tumour and non-tumour lung tissue from patients with untreated, surgically resected non-small cell lung cancer (NSCLC) within the first 100 recruited to the prospective lung TRACERx study were an..
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