Genomics of gynaecological carcinosarcomas and future treatment options
Holly E Barker, Clare L Scott
Seminars in Cancer Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2020
Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemotherapy. They are composed of both carcinomatous and sarcomatous components and are associated with high rates of metastatic disease. Due to their rarity, molecular studies have been carried out on relatively few tumours, revealing a broad spectrum of heterogeneity. In this review, we have collated the gene mutations, gene expression, epigenetic regulation and protein expression reported by a number of studies on gynaecological carcinosarcomas. Based on these results, we describe potential therapeutics that may demonstrate efficacy and present any pre-clinical studi..View full abstract
Awarded by Victorian Cancer Agency
This work was supported by fellowships from the Stafford Fox Medical Research Foundation (H.E.B. and C.L.S); Cancer Council Victoria (Sir Edward Dunlop Fellowship in Cancer Research to C.L.S.); The Victorian Cancer Agency (Clinical Fellowships CRF10-20 and CRF16014 to C.L.S.). This work was made possible through the Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Medical Research Institutes Infrastructure Support Scheme.