Journal article

State-wide utilization and performance of traditional and cell-free DNA-based prenatal testing pathways: the Victorian Perinatal Record Linkage (PeRL) study

A Lindquist, L Hui, A Poulton, E Kluckow, B Hutchinson, MD Pertile, L Bonacquisto, L Gugasyan, A Kulkarni, J Harraway, A Howden, R Mccoy, F Da Silva Costa, M Menezes, R Palma-Dias, D Nisbet, N Martin, M Bethune, Z Poulakis, J Halliday

Ultrasound in Obstetrics & Gynecology | WILEY | Published : 2020

Abstract

OBJECTIVES: Women's choices of prenatal screening and diagnostic pathways have increased in complexity since the introduction of cell-free DNA (cfDNA) screening and chromosomal microarrays. We performed individual record-linkage of women undergoing screening with cfDNA, combined first trimester screening (CFTS), second trimester serum screening (STSS), and/or prenatal and postnatal cytogenetic testing to (i) obtain population-based estimates on women's utilization of screening and diagnosis, (ii) analyse the performance of different screening strategies, and (iii) report the residual risks of any major chromosome abnormality following a low risk aneuploidy screen. METHODS: Retrospective stud..

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Grants

Awarded by NationalHealth and Medical Research Council Early Career Fellowship


Awarded by National Health and Medical Research Council Senior Research Fellowship


Funding Acknowledgements

L.H. is funded by aNationalHealth and Medical Research Council Early Career Fellowship (1105603) and J.H. was funded by a National Health and Medical Research Council Senior Research Fellowship (10121252). The funding body had no role in the conduct of the research or the writing of the manuscript.