Conference Proceedings
The genomic landscape of high-grade serous ovarian cancer in long-term survivors
Dale W Garsed, Ahwan Pandey, Sian Fereday, Kathryn Alsop, Maartje C Wouters, Flurina Saner, Jessica A Beach, Katy Milne, Catherine J Kennedy, Joy Hendley, Nadia Traficante, Celeste L Pearce, Malcolm C Pike, Susan J Ramus, Martin Kobel, Brad H Nelson, Ellen L Goode, Anna deFazio, David D Bowtell
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2019
Abstract
Abstract Purpose: The majority of patients with high-grade serous ovarian cancer (HGSC) develop progressive disease following primary treatment, with a five-year survival rate of ~30%. However, a subset of patients have an extraordinary response to treatment and ~15% survive more than ten years (long-term survivors). The Multidisciplinary Ovarian Cancer Outcomes Group (MOCOG) aims to uncover factors that influence long-term survival of HGSC patients. Here, we investigated the genomic and immunologic determinants of exceptional survival of this deadly disease. Experimental Design: Patient characteristics and clinical histories were evaluated to identify pat..
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