Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons
Stuart B Mazzone, Luyi Tian, Aung Aung Kywe Moe, Matthew W Trewella, Matthew E Ritchie, Alice E McGovern
MOLECULAR NEUROBIOLOGY | SPRINGER | Published : 2019
Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chemical environment of the airways and lungs. Subtypes are heterogenous in their responsiveness to stimuli, phenotype, and developmental origin, but they collectively serve to regulate normal respiratory and pulmonary processes and elicit a diverse range of defensive physiological responses that protect against noxious stimuli. In this study, we aimed to investigate the transcriptional features of vagal bronchopulmonary sensory neurons using single-cell RNA sequencing (scRNA-seq) to provide a deeper insight into their molecular profiles. Retrogradely labeled vagal se..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Funded by grants to S.B.M  and A.E.M  from the National Health and Medical Research Council of Australia.