Journal article

Differential Roles of Plasma Protein Corona on Immune Cell Association and Cytokine Secretion of Oligomeric and Fibrillar Beta-Amyloid

Ava Faridi, Wen Yang, Hannah Gabrielle Kelly, Chuanyu Wang, Pouya Faridi, Anthony Wayne Purcell, Thomas P Davis, Pengyu Chen, Stephen J Kent, Pu Chun Ke

Biomacromolecules | AMER CHEMICAL SOC | Published : 2019

Abstract

Alzheimer's disease (AD) is a primary neurological disease with no effective cure. A hallmark of AD is the presence of intracellular tangles and extracellular plaques derived from the aberrant aggregation of tau- and beta-amyloid (Aβ). Aβ presents in the brain as well as in cerebrospinal fluid and the circulation, and Aβ toxicity has been attributed to amyloidosis and inflammation, among other causes. In this study, the effects of the plasma protein corona have been investigated with regard to the blood cell association and cytokine secretion of oligomeric (Aβo) and fibrillar Aβ1-42(Aβf), two major forms of the peptide aggregates. Aβo displayed little change in membrane association in whole ..

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Grants

Awarded by ARC


Awarded by National Science Foundation


Awarded by National Institutes of Health


Funding Acknowledgements

This work was supported by ARC Grant CE140100036 (T.P.D.), the National Science Foundation Grant CBET-1701363 (P.C.), the National Institutes of Health Grant R35GM133795 (P.C.), and AFTAM Research Collaboration Award (T.P.D. and P.C.K.). HIM imaging was performed by Anders Barlow at the MCFP platform, University of Melbourne.