Journal article

Impact of HIV-1 viremia or sexually transmitted infection on semen-derived anti-HIV-1 antibodies and the immunosuppressive capacity of seminal plasma

Kevin J Selva, Benjamin R Bavinton, Andrew E Grulich, Marzena Pazgier, Anthony D Kelleher, Stephen J Kent, Matthew S Parsons

European Journal of Immunology | WILEY | Published : 2019

Abstract

Semen from HIV-1-infected men contains anti-HIV-1 antibodies and immunosuppressive factor(s). We assessed if suppression of viremia with antiretroviral therapy impacted seminal plasma immunosuppressive capacity or the Fc-dependent functions of seminal anti-HIV-1 antibodies. We also tested if active bacterial sexually transmitted infections altered the immunosuppressive capacity of seminal plasma.

Grants

Funding Acknowledgements

The current study was funded by grants from the National Health and Medical Research Council (NHMRC) to Matthew S Parsons and Stephen J Kent. Funding for the Opposites Attract Study was received from the NHMRC, National Health and Medical Research Council, Australia; amfAR, Foundation for AIDS Research, USA; ViiV Healthcare, UK; and Gilead Sciences, USA. The authors would like to acknowledge the Opposites Attract Study site investigators and sites participating in the Semen Sub-Study: Nittaya Phanuphak (Thai Red Cross AIDS Research Centre, Bangkok, Thailand); Beatriz Grinsztejn (Evandro Chagas Institute of Clinical Research, Rio de Janeiro, Brazil); Catherine Pell (Taylor Square Private Clinic, Sydney, Australia); Mark Bloch (Holdsworth House Medical Practice, Sydney, Australia); David Baker (East Sydney Doctors, Sydney, Australia); David J Templeton (RPA Sexual Health, Sydney, Australia); Anna M McNulty (Sydney Sexual Health Centre, Sydney, Australia); and David A Cooper (St Vincent's Hospital, Sydney, Australia). We would like to thank Dr. W.D. Tollbert from the Institute of Human Virology of the University of Maryland for mAb A32 production.