Journal article

Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease: A nine-month pilot study

Danielle M Bartlett, Juan FD Dominguez, Alpar S Lazar, Catarina C Kordsachia, Tim J Rankin, Johnny Lo, Andrew D Govus, Brian D Power, Amit Lampit, Peter R Eastwood, Mel R Ziman, Travis M Cruickshank

Journal of the Neurological Sciences | ELSEVIER | Published : 2020


BACKGROUND: Hypothalamic pathology is a well-documented feature of Huntington's disease (HD) and is believed to contribute to circadian rhythm and habitual sleep disturbances. Currently, no therapies exist to combat hypothalamic changes, nor circadian rhythm and habitual sleep disturbances in HD. OBJECTIVE: To evaluate the effects of multidisciplinary rehabilitation on hypothalamic volume, brain-derived neurotrophic factor (BDNF), circadian rhythm and habitual sleep in individuals with preclinical HD. METHODS: Eighteen individuals with HD (ten premanifest and eight prodromal) undertook a nine-month multidisciplinary rehabilitation intervention (intervention group), which included exercise, c..

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University of Melbourne Researchers


Awarded by Lotterywest grant

Awarded by Wellcome trust

Awarded by NHMRC Senior Research Fellowship

Funding Acknowledgements

This study was supported by a Lotterywest grant (MZ and TC; #107/20090827). ASL is supported by a grant from the Wellcome trust (207799/Z/17/Z). PRE is supported by a NHMRC Senior Research Fellowship (ID 1136548).