Journal article

DIETARY MODULATION OF COLONIC MUCOSAL UROKINASE ACTIVITY IN RATS

P GIBSON, M FOLINO, A MCINTYRE, O ROSELLA, C FINCH, G YOUNG

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | BLACKWELL SCIENCE PUBL AUSTR | Published : 1995

Abstract

The amount and type of dietary fibre ingested influences colonic luminal characteristics, especially the concentration of carbohydrate fermentation products such as butyrate. This study aimed to assess whether diets supplemented with fibres of differing fermentability (delivering different amounts of butyrate to the colon) influence mucosal activities of urokinase and brush border hydrolases, and epithelial turnover. Groups of five rats were fed one of four diets containing low (2%), highly fermented (guar 10% or oat bran 10%) or slowly fermented fibre (wheat bran 10%) for 4 weeks. Activities of urokinase, alkaline phosphatase, dipeptidyl peptidase IV and maltase were measured in mucosal hom..

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