Journal article

Isolating the sources of heterogeneity in nanoparticle-cell interactions

Stuart T Johnston, Matthew Faria, Edmund J Crampin

Cold Spring Harbor Laboratory

Abstract

AbstractNanoparticles have the potential to enhance therapeutic success and reduce toxicity-based treatment side effects via the targeted delivery of drugs to cells. This delivery relies on complex interactions between numerous biological, chemical and physical processes. The intertwined nature of these processes has thus far hindered attempts to understand their individual impact. Variation in experimental data, such as the number of nanoparticles inside each cell, further inhibits understanding. Here we present a mathematical framework that is capable of examining the impact of individual processes during nanoparticle delivery. We demonstrate that variation in experimental nanoparticle upt..

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University of Melbourne Researchers

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