Malawian children with uncomplicated and cerebral malaria have decreased activated V gamma 9V delta 2 gamma delta T cells which increase in convalescence
Visopo Harawa, Madi Njie, Thomas Keller, Kami Kim, Anthony Jaworowski, Karl Seydel, Stephen J Rogerson, Wilson Mandala
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2019
Malaria is responsible for almost half a million deaths annually. The role of Vγ9Vδ2 γδ T cells in malaria is still unclear. Studies have reported an association between this cell subset and malaria symptoms and severity. Profiles of Vγ9Vδ2 γδ T cells in bigger cohorts with different levels of clinical severity have not been described. Proportion, numbers, and activation status of Vγ9Vδ2 γδ T cells were measured by flow cytometry in 59 healthy controls (HCs), 58 children with uncomplicated malaria (UM) and 67 with cerebral malaria (CM,) during acute malaria and in convalescence 28 days later. Vγ9Vδ2 γδ T cell were lower in children presenting with UM and CM than in HCs. Cell counts did not v..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia, project grant APP1061993 to Stephen J Rogerson.