Insights into the Acquisition of Virulence of Avian Influenza Viruses during a Single Passage in Ferrets
Jeffrey Butler, Deborah Middleton, Jessica Haining, Rachel Layton, Steven Rockman, Lorena E Brown, Sandra Sapats
VIRUSES-BASEL | MDPI | Published : 2019
Circulating avian influenza viruses pose a significant threat, with human infections occurring infrequently but with potentially severe consequences. To examine the dynamics and locale of the adaptation process of avian influenza viruses when introduced to a mammalian host, we infected ferrets with H5N1 viruses. As expected, all ferrets infected with the human H5N1 isolate A/Vietnam/1203/2004 showed severe disease and virus replication outside the respiratory tract in multiple organs including the brain. In contrast infection of ferrets with the avian H5N1 virus A/Chicken/Laos/Xaythiani26/2006 showed a different collective pattern of infection; many ferrets developed and cleared a mild respi..View full abstract
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Awarded by Australian National Health and Medical Research Council of Australia
This research was funded by the Australian National Health and Medical Research Council of Australia, Program grant 1071916 and Project grant number 509281. J.B. was supported by a Melbourne University Research Scholarship.