Journal article

Insights into the Acquisition of Virulence of Avian Influenza Viruses during a Single Passage in Ferrets

Jeffrey Butler, Deborah Middleton, Jessica Haining, Rachel Layton, Steven Rockman, Lorena E Brown, Sandra Sapats

VIRUSES-BASEL | MDPI | Published : 2019

Abstract

Circulating avian influenza viruses pose a significant threat, with human infections occurring infrequently but with potentially severe consequences. To examine the dynamics and locale of the adaptation process of avian influenza viruses when introduced to a mammalian host, we infected ferrets with H5N1 viruses. As expected, all ferrets infected with the human H5N1 isolate A/Vietnam/1203/2004 showed severe disease and virus replication outside the respiratory tract in multiple organs including the brain. In contrast infection of ferrets with the avian H5N1 virus A/Chicken/Laos/Xaythiani26/2006 showed a different collective pattern of infection; many ferrets developed and cleared a mild respi..

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