Journal article

Switching antidepressants in the treatment of major depression: When, how and what to switch to?

Philip Boyce, Malcolm Hopwood, Grace Morris, Amber Hamilton, Darryl Bassett, Bernhard T Baune, Roger Mulder, Richard Porter, Gordon Parker, Ajeet B Singh, Tim Outhred, Pritha Das, Gin S Malhi

Journal of Affective Disorders | ELSEVIER | Published : 2020


BACKGROUND: Switching antidepressant medications is recommended when an initial antidepressant is not effective, when it is unable to be tolerated or when there are significant drug interactions. The aim of this paper is to review the evidence regarding when to switch antidepressants and the optimal approach to switching. METHODS: Clinical and academic experts in mood disorders from Australia and New Zealand (Treatment Algorithm Group, TAG) met to discuss the key considerations regarding switching antidepressants in the treatment of depression and formulate recommendations about switching strategies. RESULTS: While switching is recommended, there is limited data to guide on how best to appro..

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Funding Acknowledgements

The Treatment Algorithm Group (TAG) was supported logistically by Servier who provided financial assistance with travel and accommodation for those TAG members travelling interstate or overseas to attend the meeting in Sydney (held on 18 November 2017). None of the committee were paid to participate in this project and Servier have not had any input into the content, format or outputs from this project.