Journal article
Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis
JM Eales, AA Maan, X Xu, T Michoel, P Hallast, C Batini, D Zadik, PR Prestes, E Molina, M Denniff, J Schroeder, JLM Bjorkegren, J Thompson, P Maffia, TJ Guzik, B Keavney, MA Jobling, NJ Samani, FJ Charchar, M Tomaszewski
Arteriosclerosis Thrombosis and Vascular Biology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Open access
Abstract
OBJECTIVE: The male-specific region of the Y chromosome (MSY) remains one of the most unexplored regions of the genome. We sought to examine how the genetic variants of the MSY influence male susceptibility to coronary artery disease (CAD) and atherosclerosis. Approach and Results: Analysis of 129 133 men from UK Biobank revealed that only one of 7 common MSY haplogroups (haplogroup I1) was associated with CAD-carriers of haplogroup I1 had ≈11% increase in risk of CAD when compared with all other haplogroups combined (odds ratio, 1.11; 95% CI, 1.04-1.18; P=6.8×10-4). Targeted MSY sequencing uncovered 235 variants exclusive to this haplogroup. The haplogroup I1-specific variants showed 2.45- ..
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Awarded by Medical Research Council
Funding Acknowledgements
The work described herein was supported by British Heart Foundation grants PG/16/49/32176 (to M. Tomaszewski), PG/12/9/29376 (to M. Tomaszewski), and RE/13/5/30177 (to T.J. Guzik and P. Maffia); National Institutes of Health R01 grant HL125863 (to J.L.M. Bjorkegren); Estonian Research Council grant PUT1036 (to P. Hallast); and European Research Council grant 726318 (to T.J. Guzik). C. Batini, P. Hallast, D. Zadik, and M.A. Jobling were supported by a Wellcome Trust Senior Fellowship grant to M.A. Jobling (087576). F.J. Charchar is supported by a National Health and Medical Research Council of Australia grant (APP 1123472).