Journal article

Diagnostic stability and long-term symptomatic and functional outcomes in first-episode antipsychotic-naive patients with schizophrenia

Lea R Klaerke, Lone Baandrup, Birgitte Fagerlund, Bjorn H Ebdrup, Christos Pantelis, Birte Y Glenthoj, Mette O Nielsen



OBJECTIVE: In a prospective cohort design, we investigated: i) diagnostic stability of initially antipsychotic-naïve schizophrenia patients, ii) symptom severity including symptomatic remission, and iii) functional remission including full recovery. METHODS: We included 143 antipsychotic-naïve patients with first-episode schizophrenia or schizoaffective disorder. After 4-18 years, we clinically re-evaluated diagnosis, symptom severity and functioning for 70 patients. From the nationwide Danish registers, we extracted pragmatic outcome measures for 142 patients. We examined associations between baseline variables (age at diagnosis, sex, and premorbid intelligence) and long-term outcome status..

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University of Melbourne Researchers


Awarded by Lundbeck Foundation

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

The study was financially supported by the Lundbeck Foundation [ID: R25-A2701 and R155-2013-16337, 2013], the Mental Health Service in the Capital Region of Denmark, and Laege Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat. CP was supported by a Senior Principal Research Fellowship from the Australian National Health and Medical Research Council [NHMRC ID: 1105825, 2016] and by a grant from the Lundbeck Foundation [ID: R246-2016-3237, 2016]. The funding sources had no role in the design and conduct of the study; the collection, management, analysis and interpretation of the data; the preparation, the review or approval of the manuscript; or in the decision to submit the manuscript for publication.