Journal article

Anger and Depression in Middle-Aged Men: Implications for a Clinical Diagnosis of Chronic Traumatic Encephalopathy

Grant L Iverson, Douglas P Terry, Matthew Luz, Ross Zafonte, Paul McCrory, Gary S Solomon, Andrew J Gardner

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2019

Abstract

OBJECTIVE: In recent years, it has been proposed that problems with anger control and depression define clinical features of chronic traumatic encephalopathy (CTE). The authors examined anger problems and depression in middle-aged men from the general population and related those findings to the proposed clinical criteria for CTE. METHODS: A sample of 166 community-dwelling men ages 40-60 was extracted from the normative database of the National Institutes of Health Toolbox. All participants denied prior head injury or traumatic brain injury (TBI). Participants completed scales assessing anger, hostility, aggression, anxiety, and depression. RESULTS: In response to the item "I felt angry," 2..

View full abstract

Grants

Awarded by NIDILRR


Awarded by NIH


Awarded by USARMC


Awarded by Spaulding Research Institute


Funding Acknowledgements

Supported in part by NIDILRR (grants, 90DP0039-03-00, 90SI5007-02-04,90 D P0060), NIH (grants, 4 U01NS086090-04; 5R24HD082302-02; 5U01NS091951-03), and USARMC (grant, W81XWH-112-0210) to Dr. Zafonte.Dr. Iverson has received reimbursement from the federal government, professional scientific bodies, and commercial organizations for discussing or presenting research relating to mild traumatic brain injury (mTBI) and sport-related concussion at meetings, scientific conferences, and symposiums; he is a co-investigator, collaborator, or consultant on grants relating to mTBI funded by the federal government and other organizations; he has received research support from CNS Vital Signs, ImPACT Applications Systems, and Psychological Assessment Resources; he has received grant support from the NFL and salary support from the Harvard Integrated Program to Protect and Improve the Health of NFLPA Members; he serves as a scientific advisor to BioDirection, Highmark, and SWAY Operations; and he has received unrestricted philanthropic support from the Heinz Family Foundation, ImPACT Applications, the Mooney-Reed Charitable Foundation, and the Spaulding Research Institute. Dr. Zafonte serves on the scientific advisory boards of BioDirection, ElMINDA, Myomo, and Oxeia Biopharma; he serves as co-principal investigator on a T-32 and receives funding from the Football Players Health Study at Harvard University, which is funded by the NFL Players Association; he has received royalties from Demos Publishing and Oakstone; and he evaluates patients in the MGH Brain and Body-TRUST Program funded by the NFL Players Association. Dr. McCrory is a co-investigator on competitive grants relating to mTBI funded by several governmental and other organizations; he receives funding under a fellowship awarded by the National Health & Medical Research Council of Australia and is employed at the Florey Institute of Neuroscience and Mental Health; he has received reimbursement by the federal government, professional scientific bodies, and commercial organizations for discussing or presenting research relating to mTBI and sport-related concussion at meetings, scientific conferences, and symposiums; he has received travel reimbursements from the AFL, FIFA, and NFL; he has received unrestricted philanthropic support from CogState; and he is chairperson of the Scientific Committees of the International Concussion and Head Injury Research Foundation in London and the Sports Surgery Clinic in Dublin. Dr. Solomon has received honoraria and expense reimbursements from the federal government and professional and scientific organizations for presenting research relating to sport-related concussion at meetings, scientific conferences, and symposiums; he is employed by Vanderbilt University Medical Center; he serves as the consulting neuropsychologist for the Nashville Predators, Tennessee Titans, and the athletic departments of the University of Tennessee, Tennessee Tech University, and Vanderbilt University; and he is Senior Medical Advisor for the National Football League Department of Health and Safety. Dr.Gardner serves as a contracted concussion consultant to Rugby Australia; he has received travel funding from the Australian Football League at the Concussion in Football Conference; he has received grant support from the Brain Foundation (Australia), the Hunter Medical Research Institute (supported by Jennie Thomas and Anne Greaves), and the NSW Sporting Injuries Committee; he receives research funding via an NHMRC Early Career Fellowship, Hunter New England Local Health District, the Research, Innovation and Partnerships Health Research & Translation Centre and Clinical Research Fellowship Scheme, and the University of Newcastle's Priority Research Centre for Stroke and Brain Injury. All other authors report no financial relationships with commercial interests.