Journal article
Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity
JJ Balic, DJ Garama, MI Saad, L Yu, AC West, AJ West, T Livis, PS Bhathal, DJ Gough, BJ Jenkins
Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2019
Abstract
Deregulated activation of the latent oncogenic transcription factor STAT3 in many human epithelial malignancies, including gastric cancer, has invariably been associated with its canonical tyrosine phosphorylation and enhanced transcriptional activity. By contrast, serine phosphorylation (pS) of STAT3 can augment its nuclear transcriptional activity and promote essential mitochondrial functions, yet the role of pS-STAT3 among epithelial cancers is ill-defined. Here, we reveal that genetic ablation of pS-STAT3 in the gp130F/F spontaneous gastric cancer mouse model and human gastric cancer cell line xenografts abrogated tumor growth that coincided with reduced proliferative potential of the tu..
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Funding Acknowledgements
This work was supported by a research grant awarded by the National Health and Medical Research Council (NHMRC) of Australia to B.J. Jenkins, as well as the Operational Infrastructure Support Program by the Victorian Government of Australia. J.J. Balic was supported by an Australian Postgraduate Awards scholarship from the Australian Government. A.C. West was supported by an NHMRC Early Career Fellowship and D.J. Gough by an NHMRC Career Development Fellowship and a grant from the United States Department of Defence. B.J. Jenkins was supported by an NHMRC Senior Medical Research Fellowship.