Mother's curse and indirect genetic effects: Do males matter to mitochondrial genome evolution?
Thomas A Keaney, Heidi WS Wong, Damian K Dowling, Theresa M Jones, Luke Holman
Journal of Evolutionary Biology | WILEY | Published : 2019
Maternal inheritance of mitochondrial DNA (mtDNA) was originally thought to prevent any response to selection on male phenotypic variation attributable to mtDNA, resulting in a male-biased mtDNA mutation load ("mother's curse"). However, the theory underpinning this claim implicitly assumes that a male's mtDNA has no effect on the fitness of females he comes into contact with. If such "mitochondrially encoded indirect genetics effects" (mtIGEs) do in fact exist, and there is relatedness between the mitochondrial genomes of interacting males and females, male mtDNA-encoded traits can undergo adaptation after all. We tested this possibility using strains of Drosophila melanogaster that differ ..View full abstract
Awarded by Australian Research Council
Australian Research Council, Grant/Award Number: DP170100772