Journal article

Glycogen as a Building Block for Advanced Biological Materials

Quinn A Besford, Francesca Cavalieri, Frank Caruso

Advanced Materials | WILEY-V C H VERLAG GMBH | Published : 2019

Abstract

Biological nanoparticles found in living systems possess distinct molecular architectures and diverse functions. Glycogen is a unique biological polysaccharide nanoparticle fabricated by nature through a bottom-up approach. The biocatalytic synthesis of glycogen has evolved over time to form a nanometer-sized dendrimer-like structure (20-150 nm) with a highly branched surface and a dense core. This makes glycogen markedly different from other natural linear or branched polysaccharides and particularly attractive as a platform for biomedical applications. Glycogen is inherently biodegradable, nontoxic, and can be functionalized with diverse surface and internal motifs for enhanced biofunction..

View full abstract

Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC


Awarded by National Health and Medical Research Council


Funding Acknowledgements

This work was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). This research was also supported by the ARC under the Future Fellowship scheme (F.C., FT140100873). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). The authors gratefully acknowledge Marco Savioli, Agata Glab, and Pietro Pacchin Tomanin for assistance with illustrations and helpful discussions.