Journal article
A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, Plutella xylostella
Mark Mallott, Sarah Hamm, Bartlomiej J Troczka, Emma Randall, Adam Pym, Charles Grant, Simon Baxter, Heiko Vogel, Anthony M Shelton, Linda M Field, Martin S Williamson, Mark Paine, Christoph T Zimmer, Russell Slater, Jan Elias, Chris Bass
Insect Biochemistry and Molecular Biology | Elsevier | Published : 2019
Abstract
The diamondback moth, Plutella xylostella, is a damaging pest of cruciferous crops, and has evolved resistance to many of the insecticides used for control, including members of the diamide class. Previous work on the molecular basis of resistance to diamides has documented mutations in the target-site, the ryanodine receptor, in resistant populations of P. xylostella worldwide. In contrast the role of metabolic resistance to this insecticide class is significantly less clear. Here we show that overexpression of a flavin-dependent monooxgenase (FMO) confers resistance to the diamide chlorantraniliprole in P. xylostella. Transcriptome profiling of diamide resistant strains, with and without t..
View full abstractGrants
Awarded by European Research Council under the European Union's Horizon 2020 research and innovation programme
Awarded by Biotechnology and Biological Sciences Research Council (BBSRC Industrial CASE award)
Awarded by Syngenta (BBSRC Industrial CASE award)
Awarded by BBSRC
Awarded by Biotechnology and Biological Sciences Research Council's Industrial Strategy Challenge Fund
Funding Acknowledgements
CB received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement no 646625). CB and MM received funding from the Biotechnology and Biological Sciences Research Council and Syngenta (BBSRC Industrial CASE award number BB/K501876). CB and SH received funding from the BBSRC and Syngenta (BBSRC Industrial CASE award number BB/P504798/1). The work at Rothamsted forms part of the Smart Crop Protection (SCP) strategic programme (BBS/OS/CP/000001) funded through the Biotechnology and Biological Sciences Research Council's Industrial Strategy Challenge Fund.