Journal article

An Emerging Human Parechovirus Type 5 Causing Sepsis-Like Illness in Infants in Australia

Anthony Chamings, Kwee Chin Liew, Emily Reid, Eugene Athan, Amy Raditsis, Peter Vuillermin, Yano Yoga, Leon Caly, Julian Druce, Soren Alexandersen

VIRUSES-BASEL | MDPI | Published : 2019

Abstract

Human parechovirus (HPeV), particularly type 3 (HPeV3), is an important cause of sepsis-/meningitis-like illness in young infants. Laboratory records identified a total of ten HPeV-positive cases in Southeastern Australia between January and July 2019. The HPeV present in these cases were typed by Sanger sequencing of the partial viral capsid protein 1 (VP1) region and selected cases were further characterised by additional Sanger or Ion Torrent near-full length virus sequencing. In seven of the ten cases, an HPeV type 5 (HPeV5) was identified, and in the remaining three cases, an HPeV type 1 was identified. The HPeV5-positive cases were infants under the age of 3 months admitted to hospital..

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Grants

Awarded by CSIRO from the National Health and Medical Research Council (NHMRC)


Awarded by CSIRO from the National Health and Medical Research Council CRE Australian Partnership for Preparedness Research on Infectious Disease Emergencies


Funding Acknowledgements

This research was funded by Deakin University, Barwon Health and CSIRO, from the National Health and Medical Research Council (NHMRC), equipment grant number GNT9000413 and from the National Health and Medical Research Council CRE Australian Partnership for Preparedness Research on Infectious Disease Emergencies (APPRISE APP1116530) to S.A.