Journal article

Antimicrobial anaphylaxis: the changing face of severe antimicrobial allergy

Victoria Hall, Micah Wong, Maitri Munsif, Brittany R Stevenson, Katie Elliott, Michaela Lucas, Ashleigh J Baird, Eugene Athan, Melissa Young, Robert Pickles, Allen C Cheng, Andrew J Stewardson, Ar K Aung, Jason A Trubiano

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | OXFORD UNIV PRESS | Published : 2020

Abstract

OBJECTIVES: The epidemiology, clinical characteristics and outcomes of antimicrobial-associated anaphylaxis remain ill-defined. We sought to examine antimicrobial anaphylaxis with regard to: (i) the frequency of implicated antimicrobials; (ii) attributable mortality; and (iii) referral for definitive allergy assessment. METHODS: This was conducted through a national retrospective multicentre cohort study at five Australian tertiary hospitals (January 2010 to December 2015). Cases of antimicrobial anaphylaxis were identified from ICD-10 coding and adverse drug reaction committee databases. RESULTS: There were 293 participants meeting the case definition of antimicrobial anaphylaxis and 310 an..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by National Centre for Infections in Cancer, National Health and Medical Research Council, Centre for Research Excellence


Funding Acknowledgements

This study was supported by a National Health and Medical Research Council (NHMRC) postgraduate scholarship (GNT 1139902 to J.A.T.) and a postgraduate scholarship from The National Centre for Infections in Cancer, National Health and Medical Research Council, Centre for Research Excellence (GNT 1116876 to J.A.T.).