Journal article

A Comparison of Pneumococcal Nasopharyngeal Carriage in Very Young Fijian Infants Born by Vaginal or Cesarean Delivery

Eleanor Frances Georgina Neal, Cattram Nguyen, Felista Tupou Ratu, Silivia Matanitobua, Eileen Margaret Dunne, Rita Reyburn, Mike Kama, Rachel Devi, Kylie M Jenkins, Lisi Tikoduadua, Joseph Kado, Eric Rafai, Catherine Satzke, Edward Kim Mulholland, Fiona Mary Russell

JAMA Network Open | AMER MEDICAL ASSOC | Published : 2019

Abstract

Importance: Pneumococcal nasopharyngeal carriage is a prerequisite for pneumococcal disease. The main transmission route is from toddlers, who commonly carry pneumococci. However, neonatal pneumococcal disease case reports suggest that vertical pneumococcal transmission may also occur. Objective: To describe and compare pneumococcal nasopharyngeal carriage and density by infant mode of delivery in young Fijian infants. Design, Setting, and Participants: Annual cross-sectional surveys were performed in Suva, Fiji, before the introduction of 10-valent pneumococcal conjugate vaccine (PCV10), from September 14 to December 20, 2012, and after PCV10 was introduced, from July 11 to November 19, 201..

View full abstract

Grants

Awarded by Bill & Melinda Gates Foundation


Funding Acknowledgements

This work was supported by grants OPP1126272 and OPP1084341from the Bill & Melinda Gates Foundation, the Victorian Government's Operational Infrastructure Support Project, and the Department of Foreign Affairs and Trade of the Australian Government, the Fiji Health Sector Support Program (FHSSP). The FHSSP was implemented by Abt JTA on behalf of the Australian Government. Dr Russell held a National Health and Research Medical Council (NHMRC) Early Career Fellowship and NHMRC TRIP Fellowship; Dr Satzke holds an NHMRC Career Development Fellowship and a Veski InspiringWomen Fellowship; and Ms Neal holds an Australian Government Research Training Program Scholarship.