Journal article

An exploratory parallel-group randomised controlled trial of antenatal Guided Self-Help (plus usual care) versus usual care alone for pregnant women with depression: DAWN trial

K Trevillion, EG Ryan, A Pickles, M Heslin, S Byford, S Nath, D Bick, J Milgrom, R Mycroft, J Domoney, C Pariante, MS Hunter, LM Howard

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2020

Abstract

BACKGROUND: Depression is a common antenatal mental disorder associated with significant maternal morbidity and adverse fetal outcomes. However, there is a lack of research on the effectiveness or cost-effectiveness of psychological interventions for antenatal depression. METHODS: A parallel-group, exploratory randomised controlled trial across five hospitals. The trial compared Guided Self-Help, modified for pregnancy, plus usual care with usual care alone for pregnant women meeting DSM-IV criteria for mild-moderate depression. The trial objectives were to establish recruitment/follow-up rates, compliance and acceptability, and to provide preliminary evidence of intervention efficacy and co..

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Grants

Awarded by National Institute for Health Research (NIHR)


Awarded by NIHR Research Professorship


Funding Acknowledgements

This paper summarises independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research (PGfAR) Programme (Grant Reference Number: RP-PG-1210-12002) and the National Institute for Health Research (NIHR)/Wellcome Trust King's Clinical Research Facility. The study team acknowledges the study delivery support given by the south London NIHR Clinical Research Networks and King's Clinical Trials Unit. This study represents independent research supported by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. Louise Howard is also supported by an NIHR Research Professorship (NIHR-RP-R3-12011) and Debra Bick is also supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King's College Hospital NHS Foundation Trust. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funding source and sponsor had no role in the design, execution or dissemination of the results, other than arranging peer review.