Journal article

Synchronization lag in post stroke: relation to motor function and structural connectivity

Xin Wang, Caio Seguin, Andrew Zalesky, Wan-wa Wong, Winnie Chiu-wing Chu, Raymond Kai-yu Tong

Network Neuroscience | MIT PRESS | Published : 2019

Abstract

Stroke is characterized by delays in the resting-state hemodynamic response, resulting in synchronization lag in neural activity between brain regions. However, the structural basis of this lag remains unclear. In this study, we used resting-state functional MRI (rs-fMRI) to characterize synchronization lag profiles between homotopic regions in 15 individuals (14 males, 1 female) with brain lesions consequent to stroke as well as a group of healthy comparison individuals. We tested whether the network communication efficiency of each individual's structural brain network (connectome) could explain interindividual and interregional variation in synchronization lag profiles. To this end, conne..

View full abstract

Grants

Awarded by Research Grants Council of the Hong Kong Special Administrative Region


Awarded by Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship B


Funding Acknowledgements

Raymond Kai-yu Tong, Research Grants Council of the Hong Kong Special Administrative Region, Award ID: GRF-CUHK 14207617. Xin Wang, CUHK Global Scholarship Programme for Research Excellence. Andrew Zalesky, Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship B, Award ID: 1136649. Caio Seguin, Melbourne Research Scholarship.