The enteric nervous system undergoes significant chemical and synaptic maturation during adolescence in mice
Pavitha Parathan, Yi Wang, Anita JL Leembruggen, Joel C Bornstein, Jaime PP Foong
Developmental Biology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020
Adolescence is a critical period of development. It is very likely that there is significant maturation of the enteric nervous system (ENS) of the gut during this stage of life, especially since there are substantial changes in factors known to influence the ENS including diet and microbiota during this time, but this remains unknown. To examine maturation of the ENS during adolescence, we performed immunohistochemistry using advanced microscopy and analytical methods to compare enteric neurons and glia of the duodenum and colon of mice taken prior to weaning with those of young adult mice. We found significant changes in the architecture of both myenteric and submucosal plexuses and surpris..View full abstract
Awarded by National Health and Medical Research Council of Australia
This research was supported by National Health and Medical Research Council of Australia Project grants #1099016 (JF and JB).