Changing perspectives on how the permeation pathway through potassium channels is regulated
Katrina A Black, Ruitao Jin, Sitong He, Jacqueline M Gulbis
The Journal of Physiology | WILEY | Published : 2019
The primary means by which ion permeation through potassium channels is controlled, and the key to selective intervention in a range of pathophysiological conditions, is the process by which channels switch between non-conducting and conducting states. Conventionally, this has been explained by a steric mechanism in which the pore alternates between two conformations: a 'closed' state in which the conduction pathway is occluded and an 'open' state in which the pathway is sufficiently wide to accommodate fully hydrated ions. Recently, however, 'non-canonical' mechanisms have been proposed for some classes of K+ channels. The purpose of this review is to illuminate structural and dynamic relat..View full abstract
The project was funded by discretionary funding from The Walter and Eliza Hall Institute. The work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. R.J. and S.H. are recipients of La Trobe University Postgraduate Research Scholarships.