Journal article

Anaesthetic depth and complications after major surgery: an international, randomised controlled trial

Timothy G Short, Douglas Campbell, Christopher Frampton, Matthew TV Chan, Paul S Myles, Tomas B Corcoran, Daniel I Sessler, Gary H Mills, Juan P Cata, Thomas Painter, Kelly Byrne, Ruquan Han, Mandy HM Chu, Davina J McAllister, Kate Leslie

LANCET | ELSEVIER SCIENCE INC | Published : 2019

Abstract

BACKGROUND: An association between increasing anaesthetic depth and decreased postoperative survival has been shown in observational studies; however, evidence from randomised controlled trials is lacking. Our aim was to compare all-cause 1-year mortality in older patients having major surgery and randomly assigned to light or deep general anaesthesia. METHODS: In an international trial, we recruited patients from 73 centres in seven countries who were aged 60 years and older, with significant comorbidity, having surgery with expected duration of more than 2 h, and an anticipated hospital stay of at least 2 days. We randomly assigned patients who had increased risk of complications after maj..

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Grants

Awarded by Health Research Council of New Zealand


Awarded by Australian National Health and Medical Research Council


Awarded by Research Grants Council of Hong Kong


Awarded by National Institutes of Health in the USA


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This study was supported by grants from the Health Research Council of New Zealand (12-308-Short), the Australian National Health and Medical Research Council (APP1042727), the Research Grants Council of Hong Kong (number 61513), the National Institute for Health and Research in the UK (portfolio status), and the National Institutes of Health in the USA (P30 CA 008748). We thank Johann van Schalkwyk and Katrina Sharples, all the members of the committees overseeing the trial, and the Australian and New Zealand College of Anaesthetists Clinical Trials Network.