Systems biology and big data in asthma and allergy: recent discoveries and emerging challenges
Howard HF Tang, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2020
Asthma is a common condition caused by immune and respiratory dysfunction, and it is often linked to allergy. A systems perspective may prove helpful in unravelling the complexity of asthma and allergy. Our aim is to give an overview of systems biology approaches used in allergy and asthma research. Specifically, we describe recent "omic"-level findings, and examine how these findings have been systematically integrated to generate further insight.Current research suggests that allergy is driven by genetic and epigenetic factors, in concert with environmental factors such as microbiome and diet, leading to early-life disturbance in immunological development and disruption of balance within k..View full abstract
Related Projects (1)
Awarded by National Health and Medical Research Council
Supported by the National Health and Medical Research Council (Grant: APP1114753). Funding information for this article has been deposited with the Crossref Funder Registry.