Redox active metals in neurodegenerative diseases
Karla Acevedo, Shashank Masaldan, Carlos M Opazo, Ashley I Bush
JBIC Journal of Biological Inorganic Chemistry | Springer Science and Business Media LLC | Published : 2019
Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for brain function, including neurotransmitter synthesis and release, neurotransmission, and protein turnover. Cu and Fe are tightly regulated by sophisticated homeostatic systems that tune the levels and localization of these redox active metals. The regulation of Cu and Fe necessitates their coordination to small organic molecules and metal chaperone proteins that restrict their reactions to specific protein centres, where Cu and Fe cycle between reduced (Fe2+, Cu+) and oxidised states (Fe3+, Cu2+). Perturbation of this regulation is evident in the brain affected by neur..View full abstract
The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. This work was supported by the Australian Research Council (AIB, CO), the National Health and Medical Research Council and the CRC for Mental Health (AIB). Figures 1 and 2 were compiled using images from Servier Medical art.