Journal article

Characteristics of the Epididymal Luminal Environment Responsible for Sperm Maturation and Storage.

Wei Zhou, Geoffry N De Iuliis, Matthew D Dun, Brett Nixon

Frontiers in Endocrinology | Frontiers Media SA | Published : 2018


The testicular spermatozoa of all mammalian species are considered functionally immature owing to their inability to swim in a progressive manner and engage in productive interactions with the cumulus-oocyte complex. The ability to express these key functional attributes develops progressively during the cells' descent through the epididymis, a highly specialized ductal system that forms an integral part of the male reproductive tract. The functional maturation of the spermatozoon is achieved via continuous interactions with the epididymal luminal microenvironment and remarkably, occurs in the complete absence of de novo gene transcription or protein translation. Compositional analysis of th..

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