Journal article

Improving the estimation of the global burden of antimicrobial resistant infections

Direk Limmathurotsakul, Susanna Dunachie, Keiji Fukuda, Nicholas A Feasey, Iruka N Okeke, Alison H Holmes, Catrin E Moore, Christiane Dolecek, H Rogier van Doorn, Nandini Shetty, Alan D Lopez, Sharon J Peacock

The Lancet Infectious Diseases | ELSEVIER SCI LTD | Published : 2019


Estimating the global burden of disease from infections caused by pathogens that have acquired antimicrobial resistance (AMR) is essential for resource allocation and to inform AMR action plans at national and global levels. However, the scarcity of robust and accepted methods to determine burden is widely acknowledged. In this Personal View, we discuss the underlying assumptions, characteristics, limitations, and comparability of the approaches used to quantify mortality from AMR bacterial infections. We show that the global burdens of AMR estimated in previous studies are not comparable because of their different methodological approaches, assumptions, and data used to generate the estimat..

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Funding Acknowledgements

We thank Carmem L Pessoa Da Silva and Jean Patel for comments on the manuscript. We thank Anthony McDonnell and Jeremy Knox for comments and reviews on the models used by O'Neill in his review. We thank Ghada Zoubiane, Francesca Chiara, and Wellcome Drug-resistant infections programme team for their technical and administrative support. SEDRIC is supported by the Wellcome Drug Resistant Infection Priority Programme. The funders had no involvement in the content, writing, or submission of the paper.