Urinary Biomarkers may Complement the Cleveland Score for Prediction of Adverse Kidney Events After Cardiac Surgery: A Pilot Study
Christian Albert, Michael Haase, Annemarie Albert, Siegfried Kropf, Rinaldo Bellomo, Sabine Westphal, Mark Westerman, Ruediger Christian Braun-Dullaeus, Anja Haase-Fielitz
Annals of Laboratory Medicine | KOREAN SOC LABORATORY MEDICINE | Published : 2020
BACKGROUND: The ability of urinary biomarkers to complement established clinical risk prediction models for postoperative adverse kidney events is unclear. We assessed the effect of urinary biomarkers linked to suspected pathogenesis of cardiac surgery-induced acute kidney injury (AKI) on the performance of the Cleveland Score, a risk assessment model for postoperative adverse kidney events. METHODS: This pilot study included 100 patients who underwent open-heart surgery. We determined improvements to the Cleveland Score when adding urinary biomarkers measured using clinical laboratory platforms (neutrophil gelatinase-associated lipocalin [NGAL], interleukin-6) and those in the preclinical s..View full abstract
This study was supported by grants from the German Heart Foundation (Deutsche Stiftung fur Herzforschung) and from the Else Kroner-Fresenius-Stiftung, Germany.