Journal article

Cystatin C regulates major histocompatibility complex-II-peptide presentation and extracellular signal-regulated kinase-dependent polarizing cytokine production by bone marrow-derived dendritic cells

Wenjie Zhang, Mengting Zi, Li Sun, Fengge Wang, Shun Chen, Yanfang Zhao, Shuangchao Liang, Jiqiong Hu, Shan Liu, Lei Liu, Yifan Zhan, Andrew M Lew, Yuekang Xu

Immunology and Cell Biology | WILEY | Published : 2019

Abstract

Cystatin C is a ubiquitously expressed cysteine protease inhibitor that protects cells from either improper hydrolysis by endogenous proteases or pathogen growth/virulence by exogenous proteases. Although commonly used as a serum biomarker for evaluating renal function, cystatin C is associated with many immunological disorders under various pathophysiological conditions. How cystatin C affects immune cells, especially dendritic cells (DCs), however, is far from clear. In this study, we found that pharmacological treatment with or genetic overexpression of cystatin C in bone marrow-derived DCs (BMDCs) reduced their capacity to stimulate CD4+ T-cell proliferation, despite increased antigen up..

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