Journal article

The fitness challenge of studying molecular adaptation

David Coombes, James WB Moir, Anthony M Poole, Tim F Cooper, Renwick CJ Dobson

Biochemical Society Transactions | PORTLAND PRESS LTD | Published : 2019

Abstract

Advances in bioinformatics and high-throughput genetic analysis increasingly allow us to predict the genetic basis of adaptive traits. These predictions can be tested and confirmed, but the molecular-level changes - i.e. the molecular adaptation - that link genetic differences to organism fitness remain generally unknown. In recent years, a series of studies have started to unpick the mechanisms of adaptation at the molecular level. In particular, this work has examined how changes in protein function, activity, and regulation cause improved organismal fitness. Key to addressing molecular adaptations is identifying systems and designing experiments that integrate changes in the genome, prote..

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