Journal article

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Alexessander Couto Alves, N Maneka G De Silva, Ville Karhunen, Ulla Sovio, Shikta Das, H Rob Taal, Nicole M Warrington, Alexandra M Lewin, Marika Kaakinen, Diana L Cousminer, Elisabeth Thiering, Nicholas J Timpson, Tom A Bond, Estelle Lowry, Christopher D Brown, Xavier Estivill, Virpi Lindi, Jonathan P Bradfield, Frank Geller, Doug Speed Show all

Science Advances | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2019

Abstract

Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. Howeve..

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University of Melbourne Researchers

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Awarded by Wellcome Trust


Awarded by NIH


Awarded by NIH Genes, Environment and Health Initiative (GEI)


Awarded by NIH GEI


Awarded by Lundbeck Foundation


Awarded by Danish Medical Research Council


Awarded by Netherlands Organization for Health Research and Development


Awarded by European Union's Horizon 2020 research and innovation programme


Awarded by European Research Council (ERC)


Awarded by Academy of Finland


Awarded by World Cancer Research Fund International


Awarded by European Commission under the Marie Curie Intra-European Fellowship (project MARVEL)


Awarded by Instituto de Salud Carlos III


Awarded by Spanish Ministry of Science and Innovation


Awarded by European Commission


Awarded by Generalitat de Catalunya-CIRIT


Awarded by Federal Ministry for Environment (IUF Dusseldorf)


Awarded by National Health and Medical Research Council of Australia


Awarded by Canadian Institutes of Health Research


Awarded by Royal Society of New Zealand Marsden Fund


Awarded by University of Oulu, Finland


Awarded by European Commission (EURO-BLCS)


Awarded by NHLBI through the STAMPEED program


Awarded by NIH/NIMH


Awarded by Medical Research Council, United Kingdom


Awarded by EU


Funding Acknowledgements

All the authors acknowledge the following sponsors for support: UK Medical Research Council and Wellcome Trust (grant reference 102215/2/13/2); NIH grant R01 HD056465; Danish National Research Foundation; NIH Genes, Environment and Health Initiative (GEI; U01HG004423); NIH GEI (U01HG004438); Lundbeck Foundation (R19-A2059); Danish Medical Research Council (09-065592); French Ministry of Research; INSERM; South West NHS Research and Development; Exeter NHS Research and Development; Netherlands Organization for Health Research and Development (VIDI 016. 136. 361); European Union's Horizon 2020 research and innovation programme under grant agreement nos. 633595 (DynaHEALTH), 733206 (LIFECYCLE), and 721567 (CAPICE); European Research Council (ERC consolidator grant, ERC-2014-CoG-648916); Academy of Finland (project grants 209072 and 129255); British Heart Foundation and Academy of Finland (grants 134839 and 129287); National Public Health Institute, Helsinki, Finland; World Cancer Research Fund (WCRF UK) and World Cancer Research Fund International (2017/1641); Wellcome Trust (WT205915); European Commission under the Marie Curie Intra-European Fellowship (project MARVEL, PIEF-GA-2013-626461); Instituto de Salud Carlos III (CB06/02/0041, FIS PI041436, PI081151, PI041705, and PS09/00432 and FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, and 09/02647); Spanish Ministry of Science and Innovation (SAF2008-00357); European Commission (ENGAGE project and grant agreement HEALTH-F4-2007-201413); Fundacio La Marato de TV3; Generalitat de Catalunya-CIRIT 1999SGR 00241; Federal Ministry for Environment (IUF Dusseldorf, FKZ 20462296); National Health and Medical Research Council of Australia (grant IDs 403981 and 003209); Canadian Institutes of Health Research (grant ID MOP-82893); Royal Society of New Zealand Marsden Fund (grant 16-UOO-072); Academy of Finland (project grants 104781, 120315, 129269, 1114194, Center of Excellence in Complex Disease Genetics, and SALVE); University Hospital Oulu; Biocenter; University of Oulu, Finland (75617); European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643); NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01); NIH/NIMH (5R01MH63706:02); Medical Research Council, United Kingdom (G0500539 and G0600705, PrevMetSyn/SALVE, MR/M013138, G0802782); Wellcome Trust (project grant GR069224); and EU Framework Programme 7 EurHEALTHAgeing 277849. This research was conducted using the UK Biobank Resource. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.