The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study.
Josef Wagner, Ewan M Harrison, Marcos Martinez Del Pero, Beth Blane, Gert Mayer, Johannes Leierer, Seerapani Gopaluni, Mark A Holmes, Julian Parkhill, Sharon J Peacock, David RW Jayne, Andreas Kronbichler
Microbiome | Published : 2019
BACKGROUND: Ear, nose and throat involvement in granulomatosis with polyangiitis (GPA) is frequently the initial disease manifestation. Previous investigations have observed a higher prevalence of Staphylococcus aureus in patients with GPA, and chronic nasal carriage has been linked with an increased risk of disease relapse. In this cross-sectional study, we investigated changes in the nasal microbiota including a detailed analysis of Staphylococcus spp. by shotgun metagenomics in patients with active and inactive granulomatosis with polyangiitis (GPA). Shotgun metagenomic sequence data were also used to identify protein-encoding genes within the SEED database, and the abundance of proteins ..View full abstract
Awarded by Medical Research Council