Journal article
Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles
Z Chaudhary, GM Khan, MM Abeer, N Pujara, B Wan-Chi Tse, MA McGuckin, A Popat, T Kumeria
Biomaterials Science | ROYAL SOC CHEMISTRY | Published : 2019
DOI: 10.1039/c9bm00822e
Abstract
Photoacoustic (PA) imaging is gaining momentum due to its greater depth of field, low background, and 3D imaging capabilities. However, traditional PA imaging agents (e.g. dyes, quantum dots, etc.) are usually unstable in plasma and bind to serum proteins, and thus cleared rapidly. Because of this, the nanoparticle encapsulation of PA imaging agents is becoming increasingly popular. Therefore, the rational design of carrier nanoparticles for this purpose is necessary for strong imaging signal intensity, high biosafety, and precise targeting. Herein, we systematically evaluate the influence of the chemical and physical surface functionalization of mesoporous silica nanoparticles (MSNs) on the..
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Funding Acknowledgements
Z. C. acknowledges the Higher Education Commission (HEC) Pakistan for financial support and the University of Queensland (UQ) for research facilities. A. P. and T. K. are thankful to the National Health and Medical Research Council of Australia for Career Development and Early Career Fellowship (GNT1143296), respectively. T. K. is thankful to the University of Queensland, Faculty of Health and Behavioural Sciences (HaBS) for the collaborative seeding grants and UQ-ECR grant (UQECR1947013). The authors acknowledge the Translational Research Institute (TRI) for providing an excellent research environment and core facilities that enabled this research, particularly Dr Kamil Sokolowski from Preclinical Imaging. The authors acknowledge the Australian Research Council for funding the purchase of Vevo LAZR through a LIEF grant (LE150100067). The authors thank the University of Queensland Centre for Microscopy and Microanalysis for access to electron microscopy facility. Finally, we thank the School of Pharmacy and the University of Queensland for financial support and research facilities.