Hydroxychloroquine in dermatology: New perspectives on an old drug
Christopher Y Chew, Adrian Mar, Mandana Nikpour, Amanda M Saracino
AUSTRALASIAN JOURNAL OF DERMATOLOGY | WILEY | Published : 2019
Hydroxychloroquine is an age-old drug whose use as an immunomodulatory agent with a low side-effect profile continues to expand. We present a review of this drug including recently updated prescribing recommendations and a summary of its clinical application in dermatology. A maximum daily dose of 5.0 mg/kg based on actual body weight and no greater than 400 mg is advised in order to reduce the risk of retinopathy, which is potentially permanent and has an estimated prevalence of 7.5% at 5 years on standard dosing. Baseline ophthalmologic assessment followed by annual screening after 5 years is recommended; however, closer monitoring should be considered in the setting of existing retinopath..View full abstract
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Awarded by NHMRC Career Development Fellowship
Mandana Nikpour is supported by an NHMRC Career Development Fellowship (APP1126370).