Preoperative biomarker evaluation for the prediction of cardiovascular events after major vascular surgery
William Chan, Bronwyn A Kingwell, Hans G Schneider, Geoffrey Cox, Alaina Natoli, Jenny Starr, Kevin D Croft, Anthony M Dart, Stephen J Duffy
JOURNAL OF VASCULAR SURGERY | MOSBY-ELSEVIER | Published : 2019
OBJECTIVE: The cause of perioperative myocardial infarction (PMI) is postulated to involve hemodynamic stress or coronary plaque destabilization. We aimed to evaluate perioperative factors in patients with peripheral artery disease (PAD) undergoing major vascular surgery to determine the likely mechanisms and predictors of PMI. METHODS: This was a prospective cohort study of 133 patients undergoing major vascular surgery including open abdominal aortic aneurysm (AAA) repair (n = 40) and major suprainguinal or infrainguinal arterial bypasses (non-AAA; n = 93). Preoperative assessment with history, physical examination, and peripheral artery tonometry was performed in addition to plasma sampli..View full abstract
Awarded by National Health and Medical Research Council of Australia Early Career Fellowship (Neil Hamilton Fairley Clinical Overseas Fellowship)
W.C. is supported by the National Health and Medical Research Council of Australia Early Career Fellowship (Neil Hamilton Fairley Clinical Overseas Fellowship; APP1052960). The work of B.A.K., A.M.D., and S.J.D. is supported by National Health and Medical Research Council of Australia grants. The National Health and Medical Research Council had no involvement in the study design; collection, analysis, and interpretation of data; manuscript writing; or decision to submit the manuscript for publication.