Journal article

Nedd8 hydrolysis by UCH proteases in Plasmodium parasites

Maryia Karpiyevich, Sophie Adjalley, Marco Mol, David B Ascher, Bethany Mason, Gerbrand J van der Heden van Noort, Heike Laman, Huib Ovaa, Marcus CS Lee, Katerina Artavanis-Tsakonas

PLOS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2019

Abstract

Plasmodium parasites are the causative agents of malaria, a disease with wide public health repercussions. Increasing drug resistance and the absence of a vaccine make finding new chemotherapeutic strategies imperative. Components of the ubiquitin and ubiquitin-like pathways have garnered increased attention as novel targets given their necessity to parasite survival. Understanding how these pathways are regulated in Plasmodium and identifying differences to the host is paramount to selectively interfering with parasites. Here, we focus on Nedd8 modification in Plasmodium falciparum, given its central role to cell division and DNA repair, processes critical to Plasmodium parasites given thei..

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Grants

Awarded by Wellcome Trust Career Development Fellowship


Awarded by Biotechnology and Biological Sciences Research Council (BBSRC)


Awarded by Wellcome


Awarded by Australian National Health and Medical Research Council (NHMRC) CJ Martin Fellowship


Awarded by Jack Brockhoff Foundation


Awarded by Newton Fund RCUK-CONFAP Grant - Medical Research Council (MRC)


Awarded by Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)


Awarded by Breast Cancer Now Award


Awarded by NWO-VIDI grant


Awarded by NWO-VICI grant


Funding Acknowledgements

This work was initially supported by a Wellcome Trust Career Development Fellowship (085054/Z/08/Z) and subsequently by a Biotechnology and Biological Sciences Research Council (BBSRC) project grant (BB/R001642/1), both held by KAT. SA and MCSL are supported by a grant from Wellcome (206194). DBA is supported by an Australian National Health and Medical Research Council (NHMRC) CJ Martin Fellowship (APP1072476), the Jack Brockhoff Foundation (JBF 4186, 2016), and a Newton Fund RCUK-CONFAP Grant awarded by The Medical Research Council (MRC) and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) (MR/M026302/1). BM and HL are supported by a Breast Cancer Now Award (2013NOVPHD172). GvdHvN is supported by a NWO-VIDI grant (VI.VIDI.192.011) and HO is supported by a NWO-VICI grant (724.013.002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript