Journal article
Nedd8 hydrolysis by UCH proteases in Plasmodium parasites
M Karpiyevich, S Adjalley, M Mol, DB Ascher, B Mason, GJ van der Heden van Noort, H Laman, H Ovaa, MCS Lee, K Artavanis-Tsakonas
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2019
Open access
Abstract
Plasmodium parasites are the causative agents of malaria, a disease with wide public health repercussions. Increasing drug resistance and the absence of a vaccine make finding new chemotherapeutic strategies imperative. Components of the ubiquitin and ubiquitin-like pathways have garnered increased attention as novel targets given their necessity to parasite survival. Understanding how these pathways are regulated in Plasmodium and identifying differences to the host is paramount to selectively interfering with parasites. Here, we focus on Nedd8 modification in Plasmodium falciparum, given its central role to cell division and DNA repair, processes critical to Plasmodium parasites given thei..
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Awarded by UK Research and Innovation
Funding Acknowledgements
This work was initially supported by a Wellcome Trust Career Development Fellowship (085054/Z/08/Z) and subsequently by a Biotechnology and Biological Sciences Research Council (BBSRC) project grant (BB/R001642/1), both held by KAT. SA and MCSL are supported by a grant from Wellcome (206194). DBA is supported by an Australian National Health and Medical Research Council (NHMRC) CJ Martin Fellowship (APP1072476), the Jack Brockhoff Foundation (JBF 4186, 2016), and a Newton Fund RCUK-CONFAP Grant awarded by The Medical Research Council (MRC) and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) (MR/M026302/1). BM and HL are supported by a Breast Cancer Now Award (2013NOVPHD172). GvdHvN is supported by a NWO-VIDI grant (VI.VIDI.192.011) and HO is supported by a NWO-VICI grant (724.013.002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript