Journal article

The role of BDNF methylation and Val(66)Met in amygdala reactivity during emotion processing

Ronny Redlich, Ilona Schneider, Nicole Kerkenberg, Nils Opel, Jonas Bauhaus, Verena Enneking, Jonathan Repple, Elisabeth J Leehr, Dominik Grotegerd, Claas Kaehler, Katharina Foerster, Katharina Dohm, Susanne Meinert, Tim Hahn, Harald Kugel, Kathrin Schwarte, Christiane Schettler, Katharina Domschke, Volker Arolt, Walter Heindel Show all

Human Brain Mapping | WILEY | Published : 2019

Abstract

Epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene have been associated with psychiatric disorders in humans and with differences in amygdala BDNF mRNA levels in rodents. This human study aimed to investigate the relationship between the functional BDNF-Val66 Met polymorphism, its surrounding DNA methylation in BDNF exon IX, amygdala reactivity to emotional faces, and personality traits. Healthy controls (HC, n = 189) underwent functional MRI during an emotional face-matching task. Harm avoidance, novelty seeking and reward dependence were measured using the Tridimensional Personality Questionnaire (TPQ). Individual BDNF methylation profiles were ascertained and asso..

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University of Melbourne Researchers

Grants

Awarded by Deutsche Forschungsgemeinschaft


Awarded by Innovative Medizinische Forschung


Funding Acknowledgements

Deutsche Forschungsgemeinschaft, Grant/Award Numbers: FOR2107 DA1151/5-1, DA1151/5-2 to UD, SFB-TRR58, Project C09 to UD, SFB-TRR58, Projects C02/Z02 to KD; Innovative Medizinische Forschung, Grant/Award Numbers: DA120903, DA111107 to UD, HO221003 to CH, RE111604 to RR, RE111722 to RR; Deanery of the Medical Faculty of the University of Munster; Interdisciplinary Centre for Clinical Research