Journal article

Registration, reporting, and replication in clinical trials: The case of anorexia nervosa

Stuart B Murray, Emilio J Compte, Daniel S Quintana, Deborah Mitchison, Scott Griffiths, Jason M Nagata

International Journal of Eating Disorders | WILEY | Published : 2019

Abstract

OBJECTIVE: Treatment outcomes for anorexia nervosa (AN) remain modest, and recent research suggests that clinical trials may be of limited methodological quality. With increasing evidence illustrating the irreproducibility of psychological research, no research to date has systematically examined the cumulative effect of bias in research relating to the treatment of AN. METHOD: We identified all AN trials listed on ClinicalTrials.gov between 2000 and 2018 and examined rates of (a) the noncompletion of clinical trials, the (b) nonpublication of trials once listed as completed, (c) the nonprospective registration of clinical trials, and (d) the nonreplication of findings. RESULTS: We note that..

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Grants

Awarded by Pediatric Scientist Development Program


Awarded by Australian National Health and Medical Research Council


Awarded by Novo Nordisk Foundation


Awarded by National Institute of Mental Health


Funding Acknowledgements

American Heart Association (AHA); Pediatric Scientist Development Program, Grant/Award Number: NIH K12HD000850-33; Australian National Health and Medical Research Council, Grant/Award Number: 1121538; Novo Nordisk Foundation, Grant/Award Number: NNF160C0019856; Fulbright Commission and Argentine Ministry of Education; National Institute of Mental Health, Grant/Award Number: K23 MH115184