Journal article

Registration, reporting, and replication in clinical trials: The case of anorexia nervosa

Stuart B Murray, Emilio J Compte, Daniel S Quintana, Deborah Mitchison, Scott Griffiths, Jason M Nagata



OBJECTIVE: Treatment outcomes for anorexia nervosa (AN) remain modest, and recent research suggests that clinical trials may be of limited methodological quality. With increasing evidence illustrating the irreproducibility of psychological research, no research to date has systematically examined the cumulative effect of bias in research relating to the treatment of AN. METHOD: We identified all AN trials listed on between 2000 and 2018 and examined rates of (a) the noncompletion of clinical trials, the (b) nonpublication of trials once listed as completed, (c) the nonprospective registration of clinical trials, and (d) the nonreplication of findings. RESULTS: We note that..

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Awarded by Pediatric Scientist Development Program

Awarded by Australian National Health and Medical Research Council

Awarded by Novo Nordisk Foundation

Awarded by National Institute of Mental Health

Funding Acknowledgements

American Heart Association (AHA); Pediatric Scientist Development Program, Grant/Award Number: NIH K12HD000850-33; Australian National Health and Medical Research Council, Grant/Award Number: 1121538; Novo Nordisk Foundation, Grant/Award Number: NNF160C0019856; Fulbright Commission and Argentine Ministry of Education; National Institute of Mental Health, Grant/Award Number: K23 MH115184