Journal article

Bone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs

Rhys D Brady, Ker Rui Wong, Dale L Robinson, Richelle Mychasiuk, Stuart J McDonald, Ryan A D'Cunha, Glenn R Yamakawa, Mujun Sun, John D Wark, Peter Vee Sin Lee, Terence J O'Brien, Pablo M Casillas-Espinosa, Sandy R Shultz

Frontiers in Pharmacology | Frontiers Media | Published : 2019

Abstract

Rationale: Epilepsy patients often exhibit reduced bone mineral density and are at an increased risk of bone fracture. Whether these bone abnormalities are due to the use of anti-epileptic drugs (AED’s) or the disease itself is unknown. For example, although decreased bone health in epilepsy patients is generally attributed to the use of AED’s, seizures can also trigger a number of physiological processes that have the potential to affect bone. Therefore, to assess whether bone abnormalities occur in epilepsy in the absence of AED’s, the current study investigated mechanical characteristics and trabecular bone morphology in rats with chronic temporal lobe epilepsy. Methods: Ten-week old male..

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