Early Blood Stream Infections after BMT are Associated with Cytokine Dysregulation and Poor Overall Survival
Elizabeth M Catchpoole, Caitlin E Thirunavukarasu, Antiopi Varelias, Sanmarie Schlebusch, Stuart Olver, Nienke Zomerdijk, Emma Osland, Glen A Kennedy, Siok-Keen Tey, Geoffrey R Hill, Kate A Markey
Biology of Blood and Marrow Transplantation | ELSEVIER SCIENCE INC | Published : 2018
The key complications of allogeneic bone marrow transplantation (BMT) remain graft-versus-host disease (GVHD) and opportunistic infection. We have analyzed the blood stream infections (BSIs) occurring between day -7 and day 100 in a cohort of 184 adult patients undergoing allogeneic BMT in our center. A total of 167 of the 184 patients (91%) had blood cultures collected, and 69 (38%) patients had a confirmed BSI. Enterobacteriaceae, Pseudomonas aeruginosa, Enterococcus spp., and viridans Streptococcus spp. were the most commonly isolated organisms. Gender, conditioning (myeloablative versus reduced intensity), and donor type (sibling versus unrelated) did not differ significantly between tho..View full abstract
The authors wish to acknowledge the invaluable role of the clinical team caring for this patient group. K.A.M. is a Queensland Health Clinical Research Fellow. G.R.H. is an National Health and Medical Research Council of Australia Fellow. Cytokine analysis was funded by grants from the National Health and Medical Research Council of Australia and Leukemia Foundation Australia.