A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable
Julie Bernhardt, Kathryn S Hayward, Numa Dancause, Natasha A Lannin, Nick S Ward, Randolph J Nudo, Amanda Farrin, Leonid Churilov, Lara A Boyd, Theresa A Jones, S Thomas Carmichael, Dale Corbett, Steven C Cramer
INTERNATIONAL JOURNAL OF STROKE | SAGE PUBLICATIONS LTD | Published : 2019
A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.
Awarded by NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by Canadian Institutes of Health Research (CIHR) CaSTOR (Canadian Stroke Trials for Optimized Results) Group (CasTOR is a joint initiative of the Canadian Stroke Consortium and the Canadian Partnership for Stroke Recovery), Heart and Stroke Canadian Partnership for Stroke Recovery, and NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery (APP1077898). An unrestricted educational grant was provided by Ipsen Pharma.