Conference Proceedings

Effect of intraocular pressure on vascular autoregulation of the mouse trilaminar network

Jeremiah Kah Heng Lim, Ronald Hao Wu, Vickie Hoi Ying Wong, Algis J Vingrys, Christine Tram Oanh Nguyen, Bang V Bui

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2019

Abstract

PURPOSE. The purpose of this study was to test the hypothesis that the superficial, intermediate, and deep retinal vascular plexus show different responses to intraocular pressure (IOP) elevation. METHODS. Anesthetized adult Long Evans rats (n = 14) were imaged using optical coherence tomography angiography (OCTA; Spectralis) at baseline (IOP 10 mm Hg) and in follow-up mode to examine the vasculature during IOP elevation (10 to 110 mm Hg, 10 mm Hg steps, each step 3 minutes). A 20° × 10° field was imaged. Vessel density within a 2D projection image was determined (%) for the superficial vascular complex (SVC), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Comparison..

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Grants

Funding Acknowledgements

Support Melbourne University School of Health Sciences Early Career Grant Scheme