Multi-focal electro-retinogram response following sub-threshold nano-second laser intervention in age-related macular degeneration

Abstract

Importance: The effect of sub-threshold nano-second laser (SNL) treatment on retinal function remains unknown. Background: SNL treatment has been studied as a potential intervention in intermediate age-related macular degeneration (iAMD). This study investigated the longitudinal effect of SNL treatment on retinal function. Design: This was a sub-study of the LEAD trial; a 36-month, multi-centre, randomized and sham-controlled trial. Participants: Subjects with iAMD. Methods: Eligible participants were assigned randomly to receive SNL or sham treatment to the study eye at 6-monthly visits. Multi-focal electro-retinography (mfERG) was performed at each study visit from a study site. The mfERG ..